Environment Canada has issued a special weather statement for the area surrounding Grande Prairie, Beaverlodge, and Valleyview, as well as Whitecourt, Edson, Fox Creek, and Swan Hills.
Thirty to sixty millimetres of heavy rain is expected to fall across west Central Alberta by Wednesday night.
Although the Peace region will likely not be the worst hit, Environment Canada warns that some areas may be extra prone to flooding if the spring melt has led to high water levels.
In Grande Prairie, 10 to 15 millimetres is expected overnight, with another 30 to 40 on Wednesday.
Further warnings are likely to be issued.