Premier Alison Redford has announced her resignation effective this Sunday evening.
Her expenses and leadership style have come into question over the past while, and in the past two weeks an associate minister and a member of her government have both quit.
Redford was elected in the 2012 provincial election, after taking over leadership of the Conservative party in 2011.
She is also the second premier from her party to step down after holding the position for less than five years.
An interim replacement will be decided on.